REAL WORLD DATA

Peer-reviewed publication highlights featuring Real World Data

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Navigating research challenges with reliable data and advanced expertise

Deriving accurate and unbiased insights from real world data, particularly from claims data, can be challenging. Without careful consideration and a deep understanding of the common pitfalls associated with real world data, analysis results can be prone to bias and errors.

Clarivate experts go through great lengths to identify key strategies to address these challenges, leveraging broad ecosystem of data assets, advanced analytics, and human expertise.

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Evidence for evidence-generation

Our focus goes beyond data collection – we’re empowering transformative research and insights that shape the future of life sciences industry. Our commitment to data quality and rigorous analysis shines through the numerous peer-reviewed publications that have harnessed our Real World Data as a foundational methodology of their studies.

With an expanding catalog of over 30 peer-reviewed publications, our Real World Data stands as a dependable asset for researchers and authorities worldwide. Recognizing the indispensable role of data quality in impactful research and evidence generation, we consistently go the extra mile to identify and address gaps in our data to ensure the integrity and interpretability of analytics results.

Publications grounded in Real World Data

Company engaged in research Disease/Condition Drug/Device Publication link Recommended citation from the publishing source
Alexion Pharmaceuticals
Merck & Co.		 Neurofibromatosis type I
Plexiform neurofibroma		 Selumetinib Click here Xiaoqin Yang and others, DDEL-19. TREATMENT ADHERENCE OF SELUMETINIB AMONG PATIENTS DIAGNOSED WITH NEUROFIBROMATOSIS TYPE I AND PLEXIFORM NEUROFIBROMA IN THE UNITED STATES, Neuro-Oncology, Volume 24, Issue Supplement_7, November 2022, Page vii98, https://doi.org/10.1093/neuonc/noac209.365
Janssen Pharmaceuticals Pulmonary arterial hypertension Macitentan
Other endothelin receptor antagonists		 Click here C Worden and others, Persistence with macitentan versus other endothelin receptor antagonists in patients with pulmonary arterial hypertension: experience from a real-world data repository in the USA, European Heart Journal, Volume 43, Issue Supplement_2, October 2022, ehac544.2194, https://doi.org/10.1093/eurheartj/ehac544.2194
Gossamer Bio Pulmonary arterial hypertension
Pulmonary hypertension association		 – Click here KINGMAN, M.S. et al. (2022) ‘Real-world referral patterns of patients with pulmonary arterial hypertension (PAH) to Pulmonary Hypertension Association (pha)-accredited comprehensive care centers in the State of Texas (2019-2020)’, Chest, 162(4). doi:10.1016/j.chest.2022.08.1915.
Nestlé Gastrointestinal (GI) tracts Enteral nutrition (EN) Click here Clinical Benefits of Real Food Tube Feeding Formulas Compared to Standard Tube Feeding Formulas in Post-Acute Care Pediatric Patients. Available at: https://www.nestlemedicalhub.com/sites/default/files/2022-09/NASPGHAN%202022%20Compleat%20Ped%20Organic%20Blends%20vs%20Standard%20TF%20Clinical%20Benefits%20Poster%20.pdf
Nestlé – – Click here Cost Savings Associated With Commercial Blenderized Tube Feeding Formulas in Post-Acute Care Adult Patients. Available at: https://www.nestlemedicalhub.com/sites/default/files/2022-08/ESPEN%202022%20Cost%20Saving%20Poster%20Potrait%20Final_7_21_2022_FINAL.pdf
The University of Texas at Austin – 17-[alpha] hydroxyprogesterone caproate Click here Zhang, S., & Rascati, K. L. (2021). Utilization, adherence, and outcomes of 17-alpha hydroxyprogesterone caproate for recurrent spontaneous preterm birth prevention. Current medical research and opinion, 37(9), 1667–1675. https://doi.org/10.1080/03007995.2021.1933928
AlloVir Multiple double-stranded DNA viral infections Allogeneic hematopoietic cell transplantation Click here Hill, J.A. et al. (2022) Clinical and economic burden of multiple double-stranded DNA viral infections after allogeneic hematopoietic cell transplantation, Transplantation and Cellular Therapy, 28(9). doi:10.1016/j.jtct.2022.06.016.
University Medical Center Burn Center Burns – Click here Carter, J.E., Carson, J.S., Hickerson, W.L. et al. Length of Stay and Costs with Autologous Skin Cell Suspension Versus Split-Thickness Skin Grafts: Burn Care Data from US Centers. Adv Ther 39, 5191–5202 (2022). https://doi.org/10.1007/s12325-022-02306-y
Otsuka Pharmaceutical – Aripiprazole tablets with senso Click here Hadzi Boskovic, D. et al. (2022) ‘Rwd39 early experience with aripiprazole tablets with sensor: Patient costs from real-world data’, Value in Health, 25(7). doi:10.1016/j.jval.2022.04.1563.
Sarepta Therapeutics Duchenne muscular dystrophy – Click here Iff, J., Zhong, Y., Gupta, D., Paul, X., Tuttle, E., Henricson, E., Schrader, R., & CINRG DNHS Investigators (2022). Disease Progression Stages and Burden in Patients with Duchenne Muscular Dystrophy Using Administrative Claims Supplemented by Electronic Medical Records. Advances in therapy, 39(6), 2906–2919. https://doi.org/10.1007/s12325-022-02117-1
Daiichi Sankyo – – Click here Harris L, L’Italien G, Kumar A, et al. Real-world assessment of the relationship between migraine[1]related disability and healthcare costs in the United States. Headache. 2022;62:473–481. doi:10.1111/head.14289
BioHaven Pharmaceutical Holding Company Ltd. Migraine – Click here Harris L, L’Italien G, Kumar A, et al. Real-world assessment of the relationship between migraine[1]related disability and healthcare costs in the United States. Headache. 2022;62:473–481. doi:10.1111/head.14289
Janssen Scientific Affairs, LLC HIV-1 Darunavir
Cobicistat
Emtricitabine
Tenofovir
Alafenamide
Bictegravir
Emtricitabine
Tenofovir
Alafenamide		 Click here Emond, B., Rossi, C., Côté-Sergent, A., Bookhart, B., Anderson, D., Lefebvre, P., Lafeuille, M. H., & Donga, P. (2022). Body mass index increase and weight gain among people living with HIV-1 initiated on single-tablet darunavir/cobicistat/emtricitabine/tenofovir alafenamide or bictegravir/emtricitabine/tenofovir alafenamide in the United States. Current medical research and opinion, 38(2), 287–298. https://doi.org/10.1080/03007995.2021.2007006
Janssen Scientific Affairs, LLC HIV-1 Tenofovir alafenamide
Tenofovir disoproxil fumarate		 Click here Emond, B., Rossi, C., Rogers, R., Lefebvre, P., Lafeuille, M. H., & Donga, P. (2022). Real-World Analysis of Weight Gain and Body Mass Index Increase Among Patients with HIV-1 Using Antiretroviral Regimen Containing Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate, or Neither in the United States. Journal of health economics and outcomes research, 9(1), 39–49. https://doi.org/10.36469/jheor.2022.31825
Nestlé – – Click here LaVallee, C., Seelam, P., Balakrishnan, S., Lowen, C., Henrikson, A., Kesting, B., Perugini, M., & Araujo Torres, K. (2021). Real-World Evidence of Treatment, Tolerance, Healthcare Utilization, and Costs Among Postacute Care Adult Patients Receiving Enteral Peptide-Based Diets in the United States. JPEN. Journal of parenteral and enteral nutrition, 45(8), 1729–1735. https://doi.org/10.1002/jpen.2074
Alexion Atypical hemolytic uremic syndrome Eculizumab
Ravulizumab		 Click here Wang, Y. et al. (2021) Real-world patient characteristics, treatment patterns and outcomes for patients with atypical hemolytic uremic syndrome who have switched from eculizumab to ravulizumab in the USA, Blood, 138(Supplement 1), pp. 5003–5003. doi:10.1182/blood-2021-152598.
Nestlé Chronic pancreatitis and type 2 diabetes Pancrelipase Click here Rosenberg, Jonathan MD1; LaVallee, Chris MS2; Reddy, Manchikanti Nagarjuna BPharm, MS (Pharm)3; Seelam, Prafullakumar BE4; Li, Olivia BSc5; Pack, Jennifer MSN, ACNP-BC6; Decktor, Dennis L. PhD, FACG7. S86 Real World Evidence Evaluation of the Characteristics of Chronic Pancreatitis and Type 2 Diabetes Patients Treated With Pancrelipase in the United States. The American Journal of Gastroenterology 116():p S37, October 2021. | DOI: 10.14309/01.ajg.0000772324.35229.50
AbbVie Acute ischemic stroke – Click here Oleske, D.M. et al. (2021) Pediatric acute ischemic stroke by age-group: A systematic review and meta-analysis of published studies and Hospitalization Records, Neuroepidemiology, 55(5), pp. 331–341. doi:10.1159/000518281.
Alexion Pharmaceuticals Virus-associated hemorrhagic cystitis Allogeneic hematopoietic stem cell transplantation Click here McGuirk, J., Divine, C., Moon, S. H., Chandak, A., Zhang, Z., & Papanicolaou, G. A. (2021). Economic and Clinical Burden of Virus-Associated Hemorrhagic Cystitis in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation in the United States. Transplantation and cellular therapy, 27(6), 505.e1–505.e9. https://doi.org/10.1016/j.jtct.2021.02.021
Neurocrine Biosciences Classic congenital adrenal hyperplasia – Click here Farrar M, Farber R, Sen GP, Yonan C, Chan JL. Real-World Evidence of Clinical Outcomes in Patients With Assumed Classic Congenital Adrenal Hyperplasia in the United States. J Endocr Soc. 2021 May 3;5(Suppl 1):A93–4. doi: 10.1210/jendso/bvab048.187. PMCID: PMC8089243.
Janssen Scientific Affairs HIV Darunavir
Cobicistat
Emtricitabine
Tenofovir Alafenamide		 Click here LaVallee, C., Rascati, K. L., & Gums, T. H. (2020). Antihypertensive agent utilization patterns among patients with uncontrolled hypertension in the United States. Journal of clinical hypertension (Greenwich, Conn.), 22(11), 2084–2092. https://doi.org/10.1111/jch.14041
Sarepta Therapeutics Duchenne muscular dystrophy Eteplirsen Click here Chow W, Donga P, Côté-Sergent A, Rossi C, Lefebvre P, Lafeuille MH, Hardy H, Emond B. Treatment Patterns and Predictors of Adherence in HIV Patients Receiving Single- or Multiple-Tablet Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide. Patient Prefer Adherence. 2020 Nov 23;14:2315-2326. doi: 10.2147/PPA.S272211. PMID: 33262581; PMCID: PMC7695894.
Janssen Scientific Affairs HIV – Click here Iff, J. et al. (2020) Real-world evidence of eteplirsen treatment effects on Duchenne muscular dystrophy related health outcomes using claims data in the United States, Neuromuscular Disorders, 30. doi:10.1016/j.nmd.2020.08.288.
Boehringer Ingelheim Non-IPF Progressive Fibrosing Interstitial Lung Disease – Click here Chow, W., Donga, P., Côté-Sergent, A., Rossi, C., Lefebvre, P., Lafeuille, M. H., Emond, B., & Hardy, H. (2020). An assessment of weight change associated with the initiation of a protease or integrase strand transfer inhibitor in patients with human immunodeficiency virus. Current medical research and opinion, 36(8), 1313–1323. https://doi.org/10.1080/03007995.2020.1775074
Drexel University Schizophrenia – Click here Olson, A. L., Maher, T. M., Acciai, V., Mounir, B., Quaresma, M., Zouad-Lejour, L., Wells, C. D., & De Loureiro, L. (2020). Healthcare Resources Utilization and Costs of Patients with Non-IPF Progressive Fibrosing Interstitial Lung Disease Based on Insurance Claims in the USA. Advances in therapy, 37(7), 3292–3298. https://doi.org/10.1007/s12325-020-01380-4
GE Precision Healthcare LLC Coronary Artery Disease (CAD) – Click here Chauhan, D., Lee, B.K. and LaVallee, C. (2020) PMH29 examining healthcare utilization and costs associated with negative symptoms of schizophrenia and substance abuse disorder using real world evidence data, Value in Health, 23. doi:10.1016/j.jval.2020.04.649.
The University of Texas at Austin – 17-[alpha] hydroxyprogesterone caproate Click here Lovink, A. and Lam, F. (2020) ‘Impact of diagnostic imaging modality choice on likelihood of subsequent invasive coronary angiography in CAD patients’, Journal of the American College of Cardiology, 75(11), p. 1548. doi:10.1016/s0735-1097(20)32175-6.
Biohaven Pharma Inc. Progressive fibrosing interstitial lung diseases – Click here –
The University of Texas at Austin Diabetes mellitus (DM)
Chronic kidney disease (CKD)		 – Click here Wijsenbeek, M., Kreuter, M., Olson, A., Fischer, A., Bendstrup, E., Wells, C. D., Denton, C. P., Mounir, B., Zouad-Lejour, L., Quaresma, M., & Cottin, V. (2019). Progressive fibrosing interstitial lung diseases: current practice in diagnosis and management. Current medical research and opinion, 35(11), 2015–2024. https://doi.org/10.1080/03007995.2019.1647040
Minerva Neurosciences Schizophrenia – Click here –
Daiichi Sankyo, Inc. – – Click here Lavallee, C. et al. (2019) PMH25 real-world evidence investigation on healthcare utilization and cost among negative symptom patients and non-negative symptom patients with schizophrenia in the US, Value in Health, 22. doi:10.1016/j.jval.2019.04.1070.

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