In 2021, sales of branded biologics in ophthalmology totaled more than $9 billion in the major pharmaceutical markets (United States, EU5, and Japan). Throughout our 2021-2031 forecast period, the reference brands Lucentis (ranibizumab) and Eylea (aflibercept) are set to lose patent protection, and biosimilars will enter the market and erode both patient share and drug prices. We present our forecasts for these key reference brands and their biosimilars by molecule and country / region.
Market forecast in the major pharmaceutical markets
Major-market forecast: ophthalmology biologics
Terminology
Overarching forecast assumptions
Overview of ophthalmology biological brands in forecast
Overview of approved ophthalmology biologics
Biosimilar entry assumptions for ophthalmology biologics
Overview of biosimilars in ophthalmology disease assumptions
Drug-specific forecast assumptions
Lucentis
Outlook for Lucentis
First major-market biosimilar entrants
Order of entry in the United States
Order of entry in the EU5
Order of entry in Japan
Biosimilar uptake assumptions
Biosimilar and brand ex-manufacturer price assumptions
Lucentis sales forecast for the United States: 2021-2031
Lucentis sales forecast for the EU5: 2021-2031
Lucentis sales forecast for Japan: 2021-2031
Eylea
Outlook for Eylea
First major-market biosimilar entrants
Order of entry in the United States
Order of entry in the EU5
Order of entry in Japan
Biosimilar uptake assumptions
Biosimilar and brand ex-manufacturing price assumptions
Eylea sales forecast for the United States: 2021-2031
Eylea sales forecast for the EU5: 2021-2031
Eylea sales forecast for Japan: 2021-2031
Valentin Wasserfall
Hamzah Aideed, M.Sc., is a manager on the Biosimilars team at Clarivate. His team conducts both primary and secondary market research to provide in-depth analysis and key insights into biosimilars and the biopharmaceutical industry. Previously, Mr. Aideed was a senior research executive in consulting at McCann Health, specializing in the design and execution of advanced qualitative and quantitative research methodologies for bespoke ad-hoc consulting projects. He holds an M.Sc. in biotechnology, bioprocessing, and business management from the University of Warwick and a B.Sc. in biological chemistry from Aston University in Birmingham.