In 2021, sales of insulins at the ex-manufacturer price level exceeded $20 billion in the major pharmaceutical markets under study (United States, EU5, and Japan). Throughout our 2021-2031 forecast period, the originator insulins manufactured by Eli Lilly, Novo Nordisk, and Sanofi will face increasing competition from insulin biosimilars / follow-on insulins, eroding both patient share and drug prices. We present our forecasts for key reference brand insulins and their biosimilars / follow-on insulins by therapeutic area, molecule, and country / region.
Biosimilar entry assumptions for approved insulins
Overview of insulin biosimilar assumptions
Drug-specific forecast assumptions
Lantus
Outlook for Lantus
First major-market biosimilar entrants
Order of entry in the United States
Order of entry in the EU5
Order of entry in Japan
Biosimilar uptake assumptions
Biosimilar and brand ex-manufacturing price assumptions
Lantus sales forecast in the United States: 2021-2031
Lantus sales forecast in the EU5: 2021-2031
Lantus sales forecast in Japan: 2021-2031
Toujeo
Outlook for Toujeo
First major-market biosimilar entrants
Order of entry in the United States
Order of entry in the EU5
Biosimilar uptake assumptions
Biosimilar and brand ex-manufacturing price assumptions
Toujeo sales forecast in the United States: 2021-2031
Toujeo sales forecast in the EU5: 2021-2031
Humalog / Humalog Mix
Outlook for Humalog / Humalog Mix
First major-market biosimilar entrants
Order of entry in the United States
Order of entry in the EU5
Order of entry in Japan
Biosimilar uptake assumptions
Biosimilar and brand ex-manufacturing price assumptions
Humalog / Humalog Mix sales forecast in the United States: 2021-2031
Humalog / Humalog Mix sales forecast in the EU5: 2021-2031
Humalog / Humalog Mix sales forecast in Japan: 2021-2031
NovoLog / NovoRapid and NovoMix
Outlook for NovoLog / NovoRapid and NovoMix
First major-market biosimilar entrants (NovoLog and NovoRapid)
First major-market biosimilar entrants (NovoMix)
Biosimilar uptake assumptions
Biosimilar and brand ex-manufacturing price assumptions
NovoLog / NovoRapid sales forecast in the United States: 2021-2031
NovoLog / NovoRapid sales forecast in the EU5: 2021-2031
NovoLog / NovoRapid sales forecast in Japan: 2021-2031
NovoMix sales forecast in the United States: 2021-2031
NovoMix sales forecast in the EU5: 2021-2031
NovoMix sales forecast in Japan: 2021-2031
Rashi Tiwari
Rashi Tiwari, Pharm.D., Associate Healthcare Research and Data Analyst, Biosimilars. Prior to joining Clarivate, Dr. Tiwari was a research associate in competitive intelligence at Vyuhgenics. She earned her doctorate in pharmacy from KLE College of Pharmacy in Belagavi, where she also interned as a clinical research coordinator at KLE’s Dr. Prabhakar Kore Hospital.
Hamzah Aideed, M.Sc.
Hamzah Aideed, M.Sc., is a manager on the Biosimilars team at Clarivate. His team conducts both primary and secondary market research to provide in-depth analysis and key insights into biosimilars and the biopharmaceutical industry. Previously, Mr. Aideed was a senior research executive in consulting at McCann Health, specializing in the design and execution of advanced qualitative and quantitative research methodologies for bespoke ad-hoc consulting projects. He holds an M.Sc. in biotechnology, bioprocessing, and business management from the University of Warwick and a B.Sc. in biological chemistry from Aston University in Birmingham.